Article

Daily Medication Pearl: Aripiprazole (Abilify)

The efficacy of aripiprazole could be mediated through a combination of partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors.

Medication Pearl of the Day: Aripiprazole (Abilify)

Indication: Abilify is an atypical antipsychotic. The oral formulations are indicated for schizophrenia, acute treatment of manic and mixed episodes associated with bipolar I, adjunctive treatment of major depressive disorder, irritability associated with autistic disorder, and treatment of Tourette’s disorder.

Insight:

  • Dosing: Based on the indication, may range from 2 mg to 30 mg.
  • Dosage forms: Tablets 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, and 30 mg. Orally disintegrating tablets 10 mg and 15 mg. Oral solution 1 mg/mL. Injection 9.75 mg/1.3 mL single-dose vial.
  • Adverse events: Akathisia, restlessness, insomnia, constipation, fatigue, and blurred vision.
  • Mechanism of action: The mechanism of action of aripiprazole in schizophrenia or bipolar mania is unknown. However, the efficacy of aripiprazole could be mediated through a combination of partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors.
  • Manufacturer: Otsuka America Pharmaceuticals

Sources:

Newsletter

Stay informed on drug updates, treatment guidelines, and pharmacy practice trends—subscribe to Pharmacy Times for weekly clinical insights.

Related Videos
Image credit:  Artur | stock.adobe.com
Cardiovascular disease doctor or cardiologist holding red heart in clinic or hospital exam room office for csr professional medical service, cardiology health care and world heart health day concept - Image credit: Chinnapong | stock.adobe.com
Image credit: AwieDarwis | stock.adobe.com
Image credit: viperagp | stock.adobe.com
Image credit:  kitsawet | stock.adobe.com
Inflammation concept, inflammated human tissues 3d rendering - Image credit: picture-waterfall | stock.adobe.com