Amgen And Xencor Announce Strategic Collaboration In Cancer Immunotherapy And Inflammation
Amgen and Xencor have entered into a research and license agreement to develop and commercialize novel therapeutics in the areas of cancer immunotherapy and inflammation.
, Calif. and
Sept. 16, 2015
) (NASDAQ:XNCR) announced today that the two companies have entered into a research and license agreement to develop and commercialize novel therapeutics in the areas of cancer immunotherapy and inflammation. The research collaboration brings together
capabilities in target discovery and protein therapeutics with
bispecific technology platform.
The collaboration includes molecular engineering by
and the preclinical development of bispecific molecules for five programs proposed by
, leveraging XmAb bispecific Fc domains to make half-life extended T cell engagers and dual targeting bispecific antibodies. The agreement also includes a preclinical bispecific T cell engager program directed at CD38 and CD3 for multiple myeloma.
will be fully responsible for preclinical and clinical development and commercialization worldwide. Under the terms of the agreement,
will receive a
upfront payment and up to
in clinical, regulatory and sales milestone payments in total for the six programs.
is eligible to receive mid to high single-digit royalties for candidates directed against
targets, and high single to low double-digit royalties for
CD38 bispecific T cell engager.
"We are pleased to be joining forces with
to expand our immuno-oncology and inflammation position by leveraging
bispecific antibody platform," said
Sean E. Harper
, M.D., executive vice president of Research and Development at
. "We are especially excited about the T cell engaging bispecific antibody directed against CD38, which complements
platform, while growing our hematology and oncology portfolio that includes two bispecific T cell engager antibodies, BLINCYTO
(blinatumomab) and AMG 330, as well as Kyprolis
(carfilzomib) for relapsed multiple myeloma."
Bispecific technologies seek to engineer monoclonal antibodies to bind two unique drug targets, as opposed to traditional antibodies designed to bind to a single antigen target. This approach represents a powerful opportunity in immuno-oncology to simultaneously engage immune cells and tumor cells to localize anti-tumor immune activity where it is needed most.
, which has pioneered the use of bispecific antibodies, has chosen to access our XmAb bispecific technology for its robustness, long half-life, and the plug and play ease-of-development of our platform," said
, Ph.D., president and chief executive officer of
. "This opportunity expands the reach of our technology with a partner that has proven experience in bispecifics and immuno-oncology.
will continue to focus on its internal programs including its immuno-oncology XmAb bispecifics, XmAb14045 in acute myeloid leukemia and XmAb13676 in B-cell malignancies, which are expected to enter clinical development in 2016."