Allergan Acquires Topical Dermatology Company Topokine Therapeutics
Allergan has announced that it has acquired Topokine Therapeutics, a privately held, clinical-stage biotechnology company focused on developing topical medicines for fat reduction.
April 21, 2016
(NYSE: AGN), a leading global pharmaceutical company, today announced that it has acquired Topokine Therapeutics, a privately held, clinical-stage biotechnology company focused on developing topical medicines for fat reduction. Under the terms of the agreement,
acquired Topokine Therapeutics for an upfront payment of
and success-based development and sales milestones for
, a first-in-class topical agent in late-stage development for the treatment of steatoblepharon, also known as undereye bags.
Applied to the lower eyelids once nightly,
penetrates the skin and acts pharmacologically on fat cells to shrink undereye bags. An estimated 40 million Americans have steatoblepharon,i which can make the face look older, tired, stressed or sad. In XOPH5-OINT-2, a Phase 2 randomized, placebo-controlled clinical trial,
met the primary endpoint achieving statistically significant and clinically meaningful reductions in undereye bags. In
Topokine initiated XOPH5-OINT-3, a pivotal Phase 2b/3 study of
"The acquisition of Topokine and its
technology adds an innovative technology to
industry leading mid-to-late stage pipeline of more than 70 programs and bolsters our leadership in medical aesthetics," said
, Executive Vice President and President,
Global Brands Research & Development
has the potential to be the first topical fat reduction product for the treatment of steatoblepharon, a condition with no current therapeutic options available for patients. We look forward to continuing the outstanding development work conducted by the Topokine team to bring this innovative medical aesthetic treatment to market."
is a leader in medical and facial aesthetics, with unparalleled commercial and development expertise in the medical aesthetics community and a laser-focus on innovation. These characteristics make
ideally suited to continue the successful development and maximize the potential commercialization of
," said Murat Kalayoglu, MD, PhD, Topokine's Chief Executive Officer and a board-certified ophthalmologist. "I am deeply appreciative of the commitment and dedication of our Topokine team that has championed the discovery and development of
. We look forward to working with
to ensure continued development success for
and realize a successful launch of the product."
"Physicians and their patients have been seeking an
-approved, non-invasive treatment option to address undereye bags where current treatment options are limited," said
, MD, FRCPC, a board-certified dermatologist and director of SkinCare Physicians in
Chestnut Hill, MA.
"Adding a topical treatment that physicians could offer to their patients would be an important step forward in the treatment of steatoblepharon."
Topokine's investors include
-based private investment firm engaged in venture capital, growth equity and alternate asset investments.
Leerink Partners LLC
acted as financial advisor to Topokine.
Covington & Burling LLP
acted as legal advisor to
Foley Hoag LLP
acted as legal counsel to Topokine.