Q: Have you a formulation for chlorpromazine liquid 30mg/mL oral concentrate?
A:Chlorpromazine hydrochloride (HCl) is a white tocreamy-white, odorless powder with crystalline texture.It is very soluble in water and freely soluble in alcohol(ethanol). The commercially manufactured drug product wasdiscontinued. The following formulation was published in 2003(IJPC.7:297).
Chlorpromazine HCl 30 mg/mL Oral Concentrate (for100 mL):
Chlorpromazine HCl 3.000 g
Calcium disodium edetate 0.200 g
Citric acid 0.200 g
Saccharin sodium 0.100 g
Sodium benzoate 0.200 g
Purified water qs ad 100.000 mL
Hydroxypropyl methylcellulose 0.250 g
Propylene glycol 10.000 mL
Suggested Method of Preparation:
Chlorpromazine HCl is photosensitive. Store and dispense intight, light-resistant containers.
Labeling suggestions: "Shake well.""Must be diluted prior toadministration."
No claims are made as to the uses, safety, efficacy, orbioavailability of this product. The formula is for informationalpurposes only.
Mr. Erickson is director of professional affairs at Gallipot Inc.
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