
Learn how pharmacists guide AML care, from patient education to mutation-targeted menin inhibitors like revumenib and ziftomenib.
Menin inhibitors represent a new frontier in treating relapsed/refractory acute myeloid leukemia (AML), but understanding the nuances between revumenib and ziftomenib is critical for clinical decision-making at the pharmacy bench. Join Sanja Zepcan, PharmD, BCPS, BCOP (Loyola Medicine), and Amir Ali, PharmD, BCOP (USC Norris), for a deep dive into mechanism of action, clinical trial data, label-level distinctions, and pharmacist-led strategies for initiation. This discussion equips pharmacists with the evidence and workflows needed to optimize therapy selection, catch drug interactions, counsel on the class-defining toxicity of differentiation syndrome, and navigate access barriers in this high-acuity patient population.

Learn how pharmacists guide AML care, from patient education to mutation-targeted menin inhibitors like revumenib and ziftomenib.

Menin inhibitors offer new hope in relapsed KMT2A/MP1 AML, controlling disease to reach remission and allogeneic stem cell transplant.

Menin inhibitors show promising AML responses—revumenib enables remissions and transplant bridging, while new combinations target KMT2A and NPM1.

Choosing revimumab vs ziftomab in NPM1 AML depends on KMT2A status, transplant plans, drug interactions, adherence, and QTc monitoring.

Pharmacists compare revumenib and ziftomenib in AML—QTc thresholds, CYP3A4 interactions, acid suppression limits, and differentiation syndrome monitoring to optimize safety.

Compare revimumab and ziftomib dosing, food rules, tablet crushing, PPI interactions and half-life—key counseling tips to boost patient adherence.

In this episode, Ali outlines the non-negotiable items on the first-fill consultation checklist, including baseline ECG requirements, medication review for drug interactions, and enrollment in manufacturer support programs.

Zepcan establishes the monitoring timeline pharmacists need to implement, including QTc surveillance intervals, laboratory testing schedules, and symptom escalation protocols.

In this episode, Ali tackles the operational barriers that prevent patients from starting menin inhibitors despite being approved.

Zepcan walks through what a complete pharmacist-to-pharmacist handoff should include when a patient with AML on a menin inhibitor moves from an academic center to community care, covering dosing history, QTc and laboratory test baselines, and documented counseling.

Finally, Zepcan and Ali reflect on the single most important lessons for pharmacists new to menin inhibitor therapy and share what they wish they'd known on day one.