Mary Beth Seipel, PharmD, BCACP

Rimegepant (Nurtec) was approved by the FDA on May 27, 2021, for preventative treatment of episodic migraine in adults. Episodic migraine is defined as headaches that occur fewer than 15 days per month.

 Nurtec is the first oral calcitonin gene-related peptide (CGRP) antagonist approved for both acute and preventative treatment of migraine.

According to the National Institutes of Health, migraine-associated pain involves an intense pulsing or throbbing pain in one area of the head. It is often accompanied by nausea, vomiting, phonophobia, and/or photophobia.

Migraine is one of the leading neurological disorders and affects more than 10% of the population worldwide. Common migraine triggers include stress, anxiety, hormonal changes, weather changes, bright or flashing lights, lack of food or sleep, and dietary substances.

 Identification and avoidance of patient-specific triggers may reduce or prevent migraine attacks.

While the etiology of migraine remains less known, it is well established that CGRP—a highly potent vasodilatory protein—plays a pivotal role in its pathophysiology.

 During a migraine attack, activation of the trigeminal nerve results in neuropeptide release.

This causes neurogenic inflammation in the meningeal vasculature, which leads to mast cell degranulation, vasodilation, and activation of nociceptors. Due to knowledge regarding the role of CGRP in migraine pathophysiology, new medications specifically targeting CGRP or its receptor have been developed.

Unlike other therapies approved for migraine prevention, these agents target migraine-specific mechanisms without concern for vasoconstrictive effects.

CGRP receptor antagonists are thought to alleviate migraines though the following processes:

 CGRP receptor antagonists bind to CGRP receptors present on mast cells, which inhibits inflammation caused by the trigeminal nerve release of CGRP onto mast cells within the meninges of the brain.

CGRP receptor antagonists inhibit dilation of intracranial arteries by blocking CGRP receptors present in smooth muscle cells.

CGRP receptor antagonists bind to CGRP receptors, which results in suppression of pain through inhibition of the central relay of pain signals.

Migraine prevention: 75 mg by mouth every other day

Acute treatment of moderate to severe migraine: 75 mg by mouth daily as needed

CrCl ≥15 mL/min: no dose adjustment necessary

Mild to moderate impairment: no dose adjustment necessary

Note: Up to 18 doses of Nurtec may be taken per month

Remove Nurtec from the blister pack immediately before use and place it on or under the tongue to dissolve—no additional liquid needed.

Efficacy of Nurtec for Prevention of Episodic Migraine

Use of Nurtec 75 mg for the preventive treatment of episodic migraine was evaluated in a multi-center, double-blind, placebo-controlled, randomized clinical trial. Trial participants with ≥ 1-year history of migraine were randomized to receive every other day dosing of Nurtec 75 mg (n=373) or placebo (n=374) for 12 weeks.

Participants were allowed to remain on 1 medication with possible effects of migraine prevention if the dose was stable for a minimum of 3 months and was not expected to change during the course of the study.

: Change from baseline in the mean number of monthly migraine days (MMDs) during weeks 9-12.

≥18 years of age with ≥1-year history of migraine.

Onset of migraine prior to 50 years of age.

4-18 moderate to severe migraine attacks per month within the previous 3 months prior to the initial screening visit.

≥6 migraine days during the observation period.

≤18 headache days (migraine or non-migraine) during the observation period.

Ability to distinguish migraine attacks from tension/cluster headaches.

Individuals were excluded from trial participation if they had a history of basilar or hemiplegic migraine, were currently pregnant or breastfeeding, and/or had a history of any unstable medical conditions. Additionally, those who had been treated for (or showed evidence of) alcohol or drug abuse within the past 12 months and those who had an electrocardiogram or laboratory test finding that raised safety or tolerability concerns were not included in the trial.

Other criteria related to past medical history or comorbid conditions warranted study exclusion as further defined in the supplemental appendix. Nurtec 75 mg dosed every other day for prevention of episodic migraine demonstrated statistically significant improvements for the primary efficacy endpoint when compared to placebo, as outlined in 

Contraindications, Warnings, and Precautions

The only known contraindication to Nurtec is hypersensitivity to the medication or any component of the formulation, which may present as dyspnea, rash, or delayed serious reactions. It is recommended to discontinue therapy if hypersensitivity occurs.

Use of Nurtec is not recommended for patients with severe hepatic impairment or end-stage renal disease.

The safety of using >18 doses of Nurtec in a 30-day period has not been established.

Pregnancy and Breastfeeding Considerations

Nurtec use in women who are pregnant or breastfeeding is not recommended at this time due to lack of available evidence.

Acute treatment of moderate to severe migraine

Use of >18 tablets per 30-day period has not been established

Gastrointestinal: abdominal pain (≤ 2%), dyspepsia (≤ 2%), nausea (2-3%)

Expectations of Migraine Prevention Therapy

50% reduction in migraine attack frequency or days within 3 months

Significant decrease in duration of migraine attack

Maximal response to treatment may take 2-6 months

Nurtec use with strong CYP3A4 inhibitors is not recommended

Avoid another dose of Nurtec within 48 hours when given with a moderate CYP3A4 inhibitor

Nurtec use with strong or moderate CYP3A4 inducers is not recommended

Nurtec is a substrate of permeability glycoprotein (P-gp) and breast cancer resistance protein (BCRP) efflux transporters

Use of Nurtec with P-gp and/or BCRP inhibitors is not recommended

Nurtec is the first oralCGRP antagonist approved for the prevention of episodic migraine. Additionally, it is the only medication currently approved for both acute and preventative treatment of migraine.

Patient-specific characteristics and comorbidities should be taken into consideration when selecting a medication regimen for management of migraines. When choosing to initiate Nurtec for prevention of episodic migraine, in-depth medication counseling and appropriate monitoring of an individual’s response to therapy should be implemented.

Lipton RB, Silberstein SD. Episodic and chronic migraine headache: breaking down barriers to optimal treatment and prevention. 

Headache: The Journal of Head and Face Pain

. 2015;55:103-122. doi:10.1111/head.12505_2.

United States Food and Drug Administration

.Updated online March 19, 2020. Accessed December 11, 2021. 

https://www.fda.gov/drugs/development-approval-process-drugs/drug-trials-snapshots-nurtec-odt

Nurtec® ODT (rimegepant). Biohaven Pharmaceuticals, Inc; 2021. Updated online April 30, 2021. Accessed December 3, 2021. 

https://www.nurtec.com/?utm_source=google&utm_medium=cpc&utm_term=nurtec&gclid=CjwKCAjw2P-KBhByEiwADBYWCmvqwwyVVv7qbLSIziREwIReq7A5j6yQ76lI1tSj9obMvnhsqNiiOxoCsVQQAvD_BwE&gclsrc=aw.ds

Nurtec® ODT. In: Lexi-Drugs. Lexi-comp Online. Wolters Kluwer Health Inc. Updated September 30, 2021. Accessed December 11, 2021. 

Migraine Information Page. National Institute of Neurological Disorders and Stroke. ​Updated online December 31, 2019. Accessed November 19, 2021. 

https://www.ninds.nih.gov/Disorders/All-Disorders/Migraine-Information-Page

Edvinsson L. The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine. 

Edvinsson L, Haanes KA, Warfvinge K, et al. CGRP as the target of new migraine therapies - successful translation from bench to clinic. 

. 2018;14(6):338-350. Doi:10.1038/s41582-018-0003-1.

Durham PL, Vause CV. Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine. 

2010;24(7):539-548. doi:10.2165/11534920-000000000-00000.

Ho TW, Edvinsson L, Goadsby PJ. CGRP and its receptors provide new insights into migrainepathophysiology. 

. 2010;6(10):573-582. doi: 10.1038/nrneurol.2010.127.

Durham PL. CGRP-receptor antagonists--a fresh approach to migraine therapy? 

. 2004;350(11):1073-1075. doi:10.1056/NEJMp048016.

Nurtec® ODT. Prescribing Information. Biohaven Pharmaceuticals, Inc; 2021. Accessed December 5, 2021. 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/212728s006lbl.pdf

Croop R, Lipton RB, Kudrow D, et al. Oral rimegepant for preventive treatment of migraine: a phase 2/3 randomised, double-blind, placebo-controlled trial. 

2021;397(10268):51-60. doi: 10.1016/S0140-6736(20)32544-7.

Silberstein SD. Preventive Migraine Treatment. 

Continuum: Lifelong Learning in Neurology. 

2015;21:973-989. doi:10.1212/CON.0000000000000199.

Articles

Nurtec is the first oral calcitonin gene-related peptide antagonist approved for both acute and preventative treatment of migraine.