Daily Medication Pearl: Tolterodine Tartrate (Detrol LA)

Tolterodine Tartrate (Detrol LA) is an antimuscarinic indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

Medication Pearl of the Day: Tolterodine Tartrate (Detrol LA)

Indication: Tolterodine Tartrate (Detrol LA) is an antimuscarinic indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

Insight:

  • Dosing: 4 mg capsules taken orally once daily with water and swallowed whole; 2 mg capsules taken orally once daily with water and swallowed whole in the presence of mild to moderate hepatic impairment (Child-Pugh class A or B), severe renal impairment [Creatinine Clearance (CCr) 10–30 mL/min], and drugs that are potent CYP3A4 inhibitors.
  • Adverse events: The most common adverse reactions (incidence ≥4% and >placebo) were dry mouth, headache, constipation, and abdominal pain.
  • Mechanism of action: Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors.
  • Manufacturer: Pfizer

Reference

https://labeling.pfizer.com/showlabeling.aspx?id=719