Medication Pearl of the Day: Tolterodine Tartrate (Detrol LA)
Indication: Tolterodine Tartrate (Detrol LA) is an antimuscarinic indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.
- Dosing: 4 mg capsules taken orally once daily with water and swallowed whole; 2 mg capsules taken orally once daily with water and swallowed whole in the presence of mild to moderate hepatic impairment (Child-Pugh class A or B), severe renal impairment [Creatinine Clearance (CCr) 10–30 mL/min], and drugs that are potent CYP3A4 inhibitors.
- Adverse events: The most common adverse reactions (incidence ≥4% and >placebo) were dry mouth, headache, constipation, and abdominal pain.
- Mechanism of action: Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors.
- Manufacturer: Pfizer