Medication Pearl of the Day: Losartan Potassium (Cozaar)
Indication: Cozaar is indicated for the treatment of hypertension in adults and children over 6 years of age.
- Dosing: Usual adult dose 50 mg once daily.
- Dosage forms: Tablets 25 mg, 50 mg, and 100 mg.
- Adverse events: Most common adverse reactions (incidence ≥2% and greater than placebo) are dizziness, upper respiratory infection, nasal congestion, and back pain.
- Mechanism of action: Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues
- Manufacturer: Merck
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