While the use of preexposure prophylaxis (PrEP) against HIV has increased across the United States in recent years, the rise of PrEP costs across the health care system is yet to be fully catalogued.

Now, a team of investigators publishing in Annals of Internal Medicine have provided an estimate of out-of-pocket and third-party payments for PrEP by drawing on a database which covers more than 90% of retail pharmacy prescriptions.

The team conducted a retrospective cohort study to estimate out-of-pocket (OOP) and third-party payments using a large pharmacy database.

Data on prescriptions for the tenofovir disoproxil fumarate formulation of PrEP were taken from the IQVIA Longitudinal Prescriptions database.

“Third-party, out-of-pocket, and total payments were compared by third-party payer, classified as commercial, Medicaid, Medicare, manufacturer assistance program, or other,” study authors explained. Missing payment information was accounted for using a linear model to approximate overall PrEP payments.

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