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Opinion|Videos|December 25, 2024

Exploring Second-Line Treatments for PBC

Author(s)Ryan Haumschild, PharmD, MS, MBA, CPEL , Sandy Sallam, PharmD, BCACP, CDCES , Aparna Goel, MD

Panelists discuss how some patients with primary biliary cholangitis (PBC) have an inadequate response to ursodeoxycholic acid and require second-line treatments, with options including obeticholic acid, seladelpar, and elafibranor, which improve bile acid homeostasis and reduce inflammation.

Episodes in this series

3 experts are featured in this series.

EP. 1 Presentation and Diagnosis of Primary Biliary Cholangitis

3 experts are featured in this series.

EP. 2 Available Treatment Options for PBC

3 experts are featured in this series.

EP. 3 Treatment Goals for Patients With PBC

3 experts are featured in this series.

EP. 4 Exploring Second-Line Treatments for PBC

3 experts are featured in this series.

EP. 5 Examining Elafibranor as a Treatment Option for PBC

3 experts are featured in this series.

EP. 6 Discussing Seladelpar as a Potential Therapeutic for PBC

3 experts are featured in this series.

EP. 7 Long-Term Considerations for PBC Treatment Options

3 experts are featured in this series.

EP. 8 Safety Considerations When Initiating Treatment for PBC

3 experts are featured in this series.

EP. 9 Analyzing Hepatotoxicity as a Safety Concern With PBC Therapies

3 experts are featured in this series.

EP. 10 Additional Safety Considerations With PBC Treatments

3 experts are featured in this series.

EP. 11 Safety Profile of Second-Line Agent in Patients With Compensated Cirrhosis

3 experts are featured in this series.

EP. 12 Long-Term Safety of Second-Line Therapies for PBC

3 experts are featured in this series.

EP. 13 Best Practices in Switching PBC Therapies

3 experts are featured in this series.

EP. 14 Monitoring Patients Transitioning From Obeticholic Acid

3 experts are featured in this series.

EP. 15 Additional Considerations With PBC Therapies

Video content above is prompted by the following:

How often do patients require second-line treatments for PBC, and what agents are available for second-line management?
How do the mechanisms of action differ between seladelpar, elafibranor, and obeticholic acid?

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