Study Finds Link Between Diabetes and Alzheimer's Disease

Published Online: Thursday, August 16, 2012
Many studies have linked diabetes with the onset of Alzheimer’s disease (AD), and now a team of investigators appears to have found direct experimental evidence connecting the conditions.

“Our study identifies emergence of AD pathology in brain and retina as a major consequence of diabetes, implicating dysfunctional insulin signaling in late-onset AD, and a potential relationship between amyloid beta-derived neurotoxins and retinal degeneration in aging and diabetes, as well as AD,” the authors wrote in a study published online on July 11, 2012, in the Journal of Alzheimer’s Disease.

The researchers sought to determine how diabetes instigates late-onset AD. They examined diabetic rabbits displaying AD-type pathology for 15 weeks. After this time, investigators observed a diabetes-induced buildup of amyloid beta oligomers in the brains and retinas of the animals. Oligomers are the neurotoxins thought to cause memory loss in AD.

Another study, published in the April 2, 2012, edition of Journal of Clinical Investigation, found that the characteristics of type 2 diabetes, including abnormal glucose use, metabolic dysregulation, and insulin resistance or deficiency, are seen in the early stage of AD independent of type 2 diabetes.

The new study’s findings may have important implications for future investigation of AD pathogenesis, diagnostics, and therapeutics.

To read more articles in this watch, click:
Psoriasis Associated With Increased Risk of Diabetes Mellitus
Diabetes Drug Shown to Prompt New Cell Growth

 


Latest Articles
This weekly video program highlights the latest in pharmacy news, product news, and more.
Propranolol is red, digoxin is blue. Your pharmacist’s heart may skip a beat if they get a valentine from you.
Health-system pharmacists can play a critical role in managing drug shortages to prevent medical errors and adverse events.
The White House is asking Congress for more than $1.8 billion in emergency funding to combat the Zika virus, which is creeping into the United States and ravaging some foreign countries.
Latest Issues
$auto_registration$