Diabetes Drug Shown to Prompt New Cell Growth

Published Online: Thursday, August 16, 2012
Follow Pharmacy_Times:
The widely used diabetes drug metformin appears to encourage the growth of new brain cells, according to the results of a study published on July 6, 2012, in Cell Stem Cell. New neural cells would have the potential to help repair the effects of many neurodegenerative disorders and brain injuries.

Based on their discovery of a pathway known as PKC-CBP that signals embryonic neural stem cells to make neurons, coupled with other research that found that this pathway was activated by metformin in liver cells, the researchers theorized that metformin would activate the same pathway in neural stem cells.

The researchers found development of new neurons in the brains of mice that were taking metformin. These mice also demonstrated enhanced ability to learn and remember the route through water mazes. Finally, the researchers found that metformin promoted differentiation and genesis of human and mouse neural stem cells in culture.

“As a next step, we would be interested to see if individuals with acquired brain injury might benefit from taking metformin,” said lead researcher Freda Miller, PhD, professor in the department of molecular genetics at the University of Toronto, in a press release.

To read more articles in this watch, click:
Psoriasis Associated With Increased Risk of Diabetes Mellitus
Study Finds Link Between Diabetes and Alzheimer's Disease


Related Articles
Sanofi has announced the FDA approval of its insulin glargine injection (Toujeo), a once-daily long-acting basal insulin, for the improvement of glycemic control in adults with type 1 and type 2 diabetes.
Availability of a raw methamphetamine ingredient in popular OTC products prompted national regulations to move products that contain pseudoephedrine behind the pharmacy counter.
Novo Nordisk has positive results from a completed phase 2 trial on the oral formulation of its investigational, long-acting human glucagon-like peptide-1 analogue.
Many patients with non-alcoholic fatty liver disease also have low vitamin D levels.
Latest Issues
  • photo
    Pharmacy Times
    photo
    Health-System Edition
    photo
    Directions in Pharmacy
    photo
    OTC Guide
    photo
    Generic Supplements
  • photo
    Pharmacy Careers
    photo
    Specialty Pharmacy Times
    photo
    Generic
$auto_registration$