Vicious Cycle of Hypoglycemia and Dementia

Published Online: Monday, July 22, 2013
Follow Pharmacy_Times:
Hypoglycemia may increase the risk of dementia in older patients with type 2 diabetes, according to the results of a study published online on June 10, 2013, in JAMA Internal Medicine. Likewise, dementia patients with type 2 diabetes are more likely to experience episodes of hypoglycemia.
 
The study included almost 800 elderly patients with type 2 diabetes who were participating in the prospective population-based Health, Aging, and Body Composition Study, which was launched in 1997. At the start of the study, all participants had a score of at least 80 on the Modified Mini-Mental State Examination.
 
The researchers followed participants for 12 years, determining dementia diagnoses from hospital records for dementia-related admissions and for prescribed dementia medications. Data on hypoglycemic events were also collected from hospital records.
 
Over the study period, 61 participants (7.8%) experienced a hypoglycemic event, and 148 (18.9%) developed dementia. Patients who experienced a hypoglycemic event had a 34.4% risk for developing dementia compared with 17.6% for those who did not have a hypoglycemic event. Researchers also observed that patients who developed dementia had a 14.2% risk of a subsequent hypoglycemic event, while those without dementia had just a 6.3% risk.


Related Articles
Jennifer Costello, PharmD, BCPS, BC-ADM, ambulatory care clinical pharmacist in the Internal Medicine Faculty Practice at Saint Barnabas Medical Center in Livingston, New Jersey, talks about the benefits and risks of insulin therapy.
Jennifer Costello, PharmD, BCPS, BC-ADM, ambulatory care clinical pharmacist in the Internal Medicine Faculty Practice at Saint Barnabas Medical Center in Livingston, New Jersey, describes some ways in which pharmacists can help patients with type 2 diabetes mellitus manage their disease.
Women with a history of depression may have greater odds of developing gestational diabetes.
Prescription opioid dispensing and overdoses decreased after abuse-deterrent oxycodone hit the market and propoxyphene left it.
Latest Issues
  • photo
    Pharmacy Times
    photo
    Health-System Edition
    photo
    Directions in Pharmacy
    photo
    OTC Guide
    photo
    Generic Supplements
  • photo
    Pharmacy Careers
    photo
    Specialty Pharmacy Times
    photo
    Generic
$auto_registration$