Adenotonsillectomy for Childhood Sleep Apnea

Michele Reed, PharmD, RPh
Published Online: Tuesday, August 6, 2013
Follow Pharmacy_Times:
A recently published study evaluated the effect of early adenotonsillectomy on polysomnographic, cognitive, behavioral, and health outcomes assessed over a 7-month period.1 A total of 464 children aged 5 to 9 years with obstructive sleep apnea syndrome were randomized to a strategy of watchful waiting or early adenotonsillectomy, and outcomes were assessed at baseline and at 7 months. The primary outcome was the attention and executive-function score on the Developmental Neuropsychological Assessment.

Results showed no significant change from baseline to follow-up for the primary outcome of attention and executive-function score (mean [±SD] improvement, 7.1 ± 13.9 in the early-adenotonsillectomy group, and 5.1 ± 13.4 in the watchful-waiting group; P = .16).

Significant improvements were demonstrated in the secondary end points of behavior, quality of life, polysomnographic findings, and reduction in symptoms in the early-adenotonsillectomy group compared with the watchful-waiting group. The authors concluded that the study demonstrates beneficial effects of early adenotonsillectomy with regard to behavior, quality of life, and polysomnographic findings; however, early adenotonsillectomy did not significantly improve attention or executive function as measured by neuropsychological testing.


Dr. Reed is a freelance writer in Fairless Hills, Pennsylvania.

References
  1. Marcus CL, Moore RH, Rosen CL, et al. A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med. 2013;368(25):2366-2376.
  2. Leuppi JD, Schuetz P, Bingisser R, et al. Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA. 2013;309(21):2223-2231.
  3. Buchs NC, Konrad-Mugnier B, Jannot AS, et al. Assessment of recurrence and complications following uncomplicated diverticulitis. Br J Surg. 2013;100(7):976-979.


Related Articles
Many children with food allergies develop micronutrient deficiencies.
Shire’s ADHD treatment, lisdexamfetamine dimesylate (Vyvanse), is now available in a 10-mg titration dose.
Children born to parents with bipolar disorder have a strong likelihood of experiencing episodes of manic symptoms themselves.
The FDA today approved the first available treatment option for patients with high-risk neuroblastoma.
Latest Issues
  • photo
    Pharmacy Times
    photo
    Health-System Edition
    photo
    Directions in Pharmacy
    photo
    OTC Guide
    photo
    Generic Supplements
  • photo
    Pharmacy Careers
    photo
    Specialty Pharmacy Times
    photo
    Generic
$auto_registration$