Diana M. Sobieraj, PharmD, and Craig I. Coleman, PharmD
Published Online: Thursday, April 18, 2013 [ ]
Azithromycin and arrhythmias
MJ is a 45-year-old female patient who has a history of a purulent cough with a fever for 3 days. She complained of chest pain and difficulty breathing, and has no remarkable medical history. MJ made an appointment to see her primary care physician, who determined she had community-acquired pneumonia. MJ was given a prescription for azithromycin 250-mg tablets with instructions to take 2 tablets today and 1 tablet daily for the next 4 days. MJ approaches your pharmacy counter and is concerned because not long ago she saw a news story about the risk of azithromycin causing heart rhythm abnormalities. She asks if you believe she is at risk and if she should take the azithromycin?
Pertussis vaccination and pregnancy
SD is a 30-year-old female patient who is 30 weeks pregnant and is a patient at your pharmacy. She notices that you are able to administer vaccinations and proceeds to tell you about her best friend whose baby was diagnosed with pertussis when she was 2 months old. SD expressed that she is very concerned given the increased incidence of pertussis this year and how much her friend’s baby suffered. SD would like to know if there are any immunizations she is a candidate for that will provide her baby protection from pertussis.
Case 1: On March 12, the FDA issued a safety warning for azithromycin and the risk of potentially fatal heart rhythms. This is based on a study published in 2012 in The New England Journal of Medicine as well as a manufacturer-sponsored study. Specifically, the FDA warns that azithromycin can lead to prolongation of the QT interval and possibly lead to Torsade de pointes. Patients at particular risk are those with existing QT prolongation, low serum potassium or magnesium levels, bradycardia, or who are taking certain anti-arrhythmic drugs. In such patients, alternative antimicrobials should be considered, although the other macrolides erythromycin and clarithromycin and the fluoroquinolones ciprofloxacin and levofloxacin also carry warnings for QT interval prolongation. MJ has no remarkable medical history and therefore should not be at increased risk of arrhythmias from her azithromycin regimen. She should take the medication as prescribed.
Case 2: The Advisory Committee on Immunization Practices recommends that all pregnant women receive the Tdap vaccination regardless of prior vaccination status. The optimal window for vaccination is between 27 and 36 weeks gestation in order to maximize the passive immunity transferred to the fetus. The peak immune response is observed 2 weeks after the vaccine is given. If the woman does not receive the Tdap during her pregnancy, the vaccine should be administered immediately postpartum, which is fully compatible with breastfeeding. There is also an advantage of the female herself being protected against pertussis to reduce the likelihood of transmission to the newborn. Of note, infants are not fully protected against pertussis until they are 6 months of age and have received their third DTaP vaccine. Ideally, SD should receive the Tdap now.
Dr. Sobieraj is assistant professor of pharmacy practice and Dr. Coleman is associate professor of pharmacy practice and director of the pharmacoeconomics and outcomes studies group at the University of Connecticut School of Pharmacy.
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