Dr. Zanni is a psychologist and health-systems specialist based in Alexandria, Virginia.
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States, resulting in an estimated 57,000 deaths annually.1,2 Although CRC is among the most preventable cancers, <43% of Americans aged 50 years and older adhere to the recommended screening guidelines.3 The 5-year survival rate is 90% with early detection of this slow-growing cancer; however, 61% of CRC cases are identified after it has metastasized.4
Colonoscopy is the preferred CRC-screening procedure. Research demonstrates its improved accuracy in detecting adenomas (precancerous polyps), compared with other procedures. For example, fecal occult blood testing alone is insufficient; patients with adenomas often test negative.5
The American College of Gastroenterology (ACG) issued CRC-screening guidelines (Table) in 2000 that vary according to the following risk categories5:
The ACG recommends physicians modify guidelines consistent with the strength of known risk factors and medical histories.
Surveys reveal that patients find the preparatory regimen the most objectionable aspect of colonoscopy.7 Some patients fail to complete the preparation process because of adverse effects experienced with the prescribed purgatives.6 Colonoscopy's invasiveness is another factor fueling nonadherence; 1 survey found most patients would readily accept noninvasive procedures (eg, computed tomography scans) but are less agreeable to invasive procedures.8 Finally, some patients refuse screening because of negative reports received from their families and friends.
Bowel preparation formulations are either glycol-electrolyte lavage solution formulations (eg, Golytely, Colyte, TriLyte, HalfLytely with bisacodyl tablets, Movi-Prep) or sodium phosphate preparations, available in tablet and liquid formulations (eg, Fleet Phospho-soda, Fleet Accuprep, Visicol tablets, Osmoprep tablets). Dosages vary among products; patients must follow directions precisely.
Common side effects for both formulation categories include nausea, vomiting, abdominal cramping, and bloating. Some studies report fewer side effects with sodium phosphate tablets.6 Rare side effects include bleeding in the mucous membrane that connects the esophagus to the stomach, esophageal perforation, toxic colitis, medication malabsorption, pulmonary aspiration, hypothermia, cardiac arrhythmias, pancreatitis, inappropriate antidiuretic hormone secretion, and renal failure. Some extremely rare adverse reactions resulted in patient fatalities.6
Proper hydration is required before, during, and after colonoscopy to avoid electrolyte imbalances. Although dehydration is a significant component underlying some of the most serious adverse effects, clinicians often forget to counsel patients about volume repletion. It may seem counterintuitive that dehydration can occur when consuming 4 L of fluid; however, large amounts of fluids are required to evacuate the colon. These fluids, along with fluids in undigested food, are eliminated.
The ACG notes that decreasing dietary animal fat, increasing vegetables and dietary fiber, and increasing calcium and folic acid may help prevent colon cancer, but further study continues.2 A recent review of >7000 studies concludes that heavy consumption of red meat, especially processed meat (eg, sausage, ham, salami) increases CRC risk, as do poor diets, physical inactivity, and obesity. The same review recommends consuming <18 oz of red meat per week.10
Researchers are refining diagnostic alternatives, and the virtual colonoscopy holds promise for the future. Until then, health professionals must promote the importance of colonoscopy. Some patients find the topic difficult and embarrassing to discuss and feel more comfortable with written information. The National Institute of Diabetes and Digestive and Kidney Diseases publishes an excellent, easy-to-understand brochure on colonoscopy that can be found at digestive.niddk.nih.gov/ddiseases/pubs/colonoscopy. Many patients take complimentary copies placed on the counter; therefore, this method is recommended.
The Oncology Care Pharmacist in Health-System Pharmacy
According to the National Cancer Institute, almost 40% of men and women will be given a diagnosis of some form of cancer in their lifetime.
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