Anna D. Garrett, PharmD, BCPS, CPP
Published Online: Sunday, October 1, 2006

A recent warning issued by the FDA cautions health care providers regarding a potential interaction between lowdose aspirin and ibuprofen. Ex vivo studies have shown that ibuprofen interferes with the antiplatelet effects of aspirin (81 mg immediate-release). This interaction appears to be most significant when ibuprofen is taken within 30 minutes after taking aspirin. The FDA states in the warning:

  • Occasional use of ibuprofen is likely to cause minimal risk
  • Spacing of ibuprofen at least 30 minutes after, or more than 8 hours before, aspirin ingestion is suggested
  • This problem exists only with immediate-release aspirin.

Dr. Garrett is a clinical pharmacist practitioner at Cornerstone Health Care in High Point, NC.

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