A phase 3, randomized, open-label, multicenter study was conducted at 44 sites in Europe to evaluate 2 different doses of Wyeth's oral levonorgestrel (LNG) and ethinyl estradiol (EE) over 1 year: continuous daily, noncyclic LNG 90 μg/EE 20 μg and 21-day cyclic LNG 100 μg/EE 20 μg. The study involved ~641 women who took either version of the oral contraceptive in the form of 13 pill packs over the course of 12 months. The study authors noted that a majority of women taking the continuous daily LNG/EE combination reported amenorrhea: 27.1% at pill pack 3, 39.6% at pill pack 7, and 52.9% at pill pack 13. The researchers also noted an increase in the percentage of participants who experienced no bleeding with subsequent pill packs: 50%, 69%, and 79% at packs 3, 7, and 13, respectively. The researchers concluded that these results showed that the noncyclic regimen has a similar safety profile, compared with the established 21- day regimen. The study results were presented at the Annual Meeting of the American College of Obstetricians and Gynecologists on May 8, 2006.
Ms. Farley is a freelance medical writer based in Wakefield, RI.
One study linked multiple pregnancies to an increased risk of developing atrial fibrillation later in life, and another investigated the association between premature delivery and cardiovascular disease.
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