Trazodone for Insomnia: Worth the Risk?

MAY 01, 2006

The antidepressant trazodone is currently the second most commonly prescribed treatment for insomnia because of its sedative properties, perceived lack of risk, generic availability, and lack of duration-of-use restrictions. Whereas trazodone is not approved to treat insomnia, relatively few studies actually support its efficacy and safety.

A literature review of clinical trial data concerning trazodone, reported in the Journal of Clinical Psychiatry (April 2005), confirmed the lack of evidence for its effectiveness as an insomnia therapy.A high rate of discontinuation due to adverse effects accompanied the use of trazodone, as did the potential for drug tolerance. The author concluded that risk/benefit considerations may not warrant trazodone use in nondepressed and/or elderly insomnia patients.




SHARE THIS SHARE THIS
0
 

In Seniors: Consider CMV Serostatus
When Recommending Flu Vaccine

Older people who have cytomegalovirus seem to have less robust responses to the trivalent influenza vaccine than those who do not have CMV.


 

 

Conference Coverage
News from the year's biggest meetings


Pharmacist Education
Clinical features with downloadable PDFs


 

SIGN UP FOR THE PHARMACY TIMES NEWSLETTER
Personalize the information you receive by selecting targeted content and special offers.