A pilot study of Endo Pharmaceuticals' topical analgesic patch, lidocaine patch 5% (Lidoderm), showed a significant reduction in pain intensity, as well as a high satisfaction level among patients using the patch. Twenty patients treated with Lidoderm achieved a 41.5% reduction in mean pain intensity as measured by the Brief Pain Inventory. Another 20 patients received a single corticosteroid injection into the carpal tunnel and achieved a 43.8% reduction in pain intensity. Results also showed that 80% of patients treated with Lidoderm reported being "satisfied" or "very satisfied" with the treatment; investigators noted improvements in 88% of their patients. Among patients in the injection group, 59% reported being "satisfied" or "very satisfied" with their treatment, and investigators noted an overall 74% improvement in these patients. Study author Srinivas Nalamachu, MD, of the University of Medicine and Biosciences in Kansas City, Mo, commented, "We are excited to find a noninvasive, topical patch appeared to alleviate these patients' carpal-tunnel-syndrome-related pain." These results still need to be confirmed in a larger, double-blind, placebo-controlled study.
Ms. Farley is a freelance medical writer based in Wakefield, RI.
One study linked multiple pregnancies to an increased risk of developing atrial fibrillation later in life, and another investigated the association between premature delivery and cardiovascular disease.
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