Relieving gastroesophageal reflux disease (GERD) can improve sleep quality. This conclusion was reached in the first major multicenter, randomized, double-blind, placebo-controlled trial focusing on GERD therapy and sleep disorders.
The study, reported in the American Journal of Gastroenterology (September 2005), showed that effective acid-suppression therapy with 20 or 40 mg of a proton pump inhibitor, such as esomeprazole, worked on nighttime heartburn symptoms and GERD-related sleep disturbances.
"Sleep problems are extremely common in patients with GERD and are often unrecognized," said lead investigator David Johnson, MD. For patients with frequent and moderate-to-severe symptoms, GERD has a considerably negative impact on sleep.
One study linked multiple pregnancies to an increased risk of developing atrial fibrillation later in life, and another investigated the association between premature delivery and cardiovascular disease.
Clinical features with downloadable PDFs