Diuretic Best BP Therapy for African Americans

Susan Farley
Published Online: Saturday, October 1, 2005

A large clinical trial known as ALLHAT compared different blood pressure treatments. The results showed that, for African American hypertensives, newer drugs may not be better than diuretics, regardless of the presence of metabolic syndrome. The ALLHAT group reviewed heart and kidney complications for more than 18,100 patients with hypertension and metabolic syndrome?which included 5763 African Americans?and another group of 11,180 patients without metabolic syndrome?which included 4277 African Americans. All study participants were randomly assigned to receive either a diuretic (chlorthalidone), a calcium channel blocker (amlodipine), or an angiotensin-converting enzyme (ACE) inhibitor (lisinopril). After 5 years, researchers found that neither the ACE inhibitor nor the calcium channel blocker was more effective than the diuretic in preventing cardiovascular incidents in patients with or without metabolic syndrome.

Ms. Farley is a freelance medical writer based in Wakefield, RI.

Latest Articles
This weekly video program provides our readers with an in-depth review of the latest news, product approvals, FDA rulings and more.
Chronic kidney disease incidence has grown faster than many of its common comorbidities such as diabetes and hypertension, and medications may be an underappreciated driver of this growth.
President Barack Obama’s fiscal year 2017 budget proposal calls for an additional $1.1 billion to combat the nation’s spiraling opioid epidemic.
Baxter International is voluntarily recalling intravenous solution due to leaking containers and the potential for particulate matter.
Latest Issues