Despite many advances in treating diabetes, the majority of adults with the disease have not reached the appropriate HbA1C goal. Reporting in the American Journal of Managed Care (April 2005), Kaiser Permanente conducted the first head-to-head analysis of the use of all current available treatments for diabetes. The study involved 4775 members of Kaiser Permanente Northern California Group.
The study's findings showed that >80% of badly controlled adults with type 2 diabetes who started new antidiabetic therapies did not achieve recommended glycemic targets (HbA1C ≤7%) within 1 year. The researchers suggested the need for more aggressive and earlier intensification of established therapies; less waiting time with quick progression from single therapy to combination therapy with or without insulin; and further investigation of ways to incorporate behavioral change.