Researchers in the United Kingdom found 3 cases linking lipid abnormalities with rosiglitazone. The study showed that treatment with rosiglitazone might cause an acute decrease in high-density lipoprotein (HDL; "good") cholesterol and an increase in fasting triglycerides. Reporting in Diabetes Care (November 2004), the researchers said that the 3 participants had type 2 diabetes and high cholesterol and were being treated with rosiglitazone. The results of the study indicated that rosiglitazone was temporally related to a drastic decline in HDL cholesterol.
Once the drug was stopped, the patients had a rapid return of HDL cholesterol to pretreatment levels. All 3 patients had a "striking improvement" in blood sugar control with rosiglitazone treatment even with the abnormal cholesterol response. The researchers noted that the mechanism of rosiglitazone-induced cholesterol abnormalities remains to be determined. Although the cholesterol problem was rare, the researchers recommended that a full lipid profile, including HDL cholesterol, be taken prior to beginning rosiglitazone and similar drugs and again 3 months later.
In Seniors: Consider CMV Serostatus
When Recommending Flu Vaccine
Older people who have cytomegalovirus seem to have less robust responses to the trivalent influenza vaccine than those who do not have CMV.
News from the year's biggest meetings
Clinical features with downloadable PDFs