Acid-Related Diseases Are Prevalent

Published Online: Thursday, April 1, 2004

Acid-related disorders?including gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), and dyspepsia?are common in the United States. In the November 2003 issue of the American Journal of Gastroenterology, Sumit R. Majumdar, MD, MPH, and colleagues reported their findings from a population-based cohort study of 216,720 members of a managed care organization. The study focused on the prevalence of chronic acid-related disorders and rates of adherence to current guidelines for the investigation of PUD and dyspepsia.

The results demonstrated that 2.3% of this patient population had chronic acid-related disorders that required the use on a long-term basis ( 1 year) of prescription acid-suppressing medications, including histamine type 2 blockers and proton pump inhibitors (PPIs). Among patients with chronic acid-related disorders (n = 5064), 59% had GERD, 35% had presumptive dyspepsia (82% of whom were not investigated by endoscopy), and 6% had PUD (34% of whom had never been tested for Helicobacter pylori infection). The use of PPI monotherapy was highest among patients with GERD (31%) and lowest among patients with uninvestigated dyspepsia (12%).

Although chronic acid-related disorders and long-term use of acid-suppressing medications are common among primary care patients, the authors conclude that these patients are underinvestigated.

Latest Articles
A pharmacy robber not only left his fingerprints behind at a pharmacy—he also dropped his wallet containing his identification as he made his escape.
Janssen Research and Development LLC has submitted a new drug application to the FDA for canagliflozin and metformin hydrochloride extended release (Invokamet XR).
Treating chronic pulmonary obstructive disease with both inhaled corticosteroids and long-acting bronchodilators remains controversial, but new evidence suggests that this controller combination could reduce mortality risk.
Beverly Schaefer, RPh, of Katterman's Sand Point Pharmacy in Seattle, Washington, shares some fun tips on how to encourage patients who travel to come to your pharmacy for supplies.
Latest Issues