A report published in the Archives of Neurology (January 2003) indicated that people with a polymorphism in the CYP46 gene are at increased risk for late-onset Alzheimer?s disease (AD). According to researchers, this gene encodes cholesterol 24-hydroxylase, and previous studies have shown that reducing cholesterol levels in the brain inhibits the generation of beta-amyloid peptides found in AD plaques.
The study compared 201 patients with AD with 248 control subjects to assess the CYP46 genotype and the frequency of a particular polymorphism. Researchers found the CYP46*TT genotype to be significantly more common among the patients with AD. The study authors concluded that ?these data are consistent with the possibility that CYP46 is a novel susceptibility gene for Alzheimer?s disease.?
One study linked multiple pregnancies to an increased risk of developing atrial fibrillation later in life, and another investigated the association between premature delivery and cardiovascular disease.
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