Alzheimer's Disease Due to Cholesterol?

Published Online: Saturday, March 1, 2003

A report published in the Archives of Neurology (January 2003) indicated that people with a polymorphism in the CYP46 gene are at increased risk for late-onset Alzheimer?s disease (AD). According to researchers, this gene encodes cholesterol 24-hydroxylase, and previous studies have shown that reducing cholesterol levels in the brain inhibits the generation of beta-amyloid peptides found in AD plaques.

The study compared 201 patients with AD with 248 control subjects to assess the CYP46 genotype and the frequency of a particular polymorphism. Researchers found the CYP46*TT genotype to be significantly more common among the patients with AD. The study authors concluded that ?these data are consistent with the possibility that CYP46 is a novel susceptibility gene for Alzheimer?s disease.?



Latest Articles
This weekly video program provides our readers with an in-depth review of the latest news, product approvals, FDA rulings and more.
Chronic kidney disease incidence has grown faster than many of its common comorbidities such as diabetes and hypertension, and medications may be an underappreciated driver of this growth.
President Barack Obama’s fiscal year 2017 budget proposal calls for an additional $1.1 billion to combat the nation’s spiraling opioid epidemic.
Baxter International is voluntarily recalling intravenous solution due to leaking containers and the potential for particulate matter.
Latest Issues
$auto_registration$
VSEO N/A