Upper and Lower Airways Are Connected in Allergic Disease

Published Online: Saturday, March 1, 2003

The results of a new study provide further evidence of the connection between the upper and lower airways in allergic disease.

Researchers developed a model of allergic rhinitis in order to study how the upper and lower airways respond when allergens are deposited only in the nasal cavity, as reported in the Journal of Allergy and Clinical Immunology (December 2002, part 1). The investigators sensitized 6- to 8-week-old mice with ovalbumin, an egg protein and common allergen, administered through the nose. The mice were then challenged with the ovalbumin to initiate an allergic response. The results showed that allergic inflammation occurred in both the upper airway and the lower airway, despite the fact that little or no allergen was detected in the lungs.

Latest Articles
Pharmacists might be surprised to learn that Pinterest is a hotbed for anti-vaccine sentiment.
The FDA has approved betamethasone dipropionate spray, 0.05%, as a treatment for mild to moderate plaque psoriasis in patients aged 18 years and older.
Medication errors injure thousands of patients annually, and while mistakes occur with all medication classes, those involving antiretroviral therapies are particularly troublesome.
Acute respiratory infections such as the common cold are often accompanied by cough and congestion caused by mucus hypersecretion.
Latest Issues