Nicotine Antagonist Relieves Depression in Children with Tourette!s Syndrome

FEBRUARY 01, 2003

The nicotine antagonist mecamylamine appears to relieve depression and mood instability in children and adolescents with Tourette?s syndrome, according to a preliminary study reported in Depression and Anxiety. The study involved 38 children and adolescents diagnosed with Tourette?s syndrome and at least 1 of several mood disorders. Of the 38 patients, 17 received mecamylamine and 21 received placebo. The 4 patients diagnosed with Tourette?s syndrome plus major depression showed the greatest improvements in behavioral and emotional symptoms, including significant decreases in sudden mood changes, irritability, demanding attention, inattention, restlessness, anxiety, and impulsiveness. The medication?s most beneficial effect appeared to be stabilizing mood. ?This is the first clinical evidence supporting the hypothesis that many antidepressants function, in part, by inhibiting nicotinic receptors,? said lead author Douglas Shytle, PhD.



SHARE THIS SHARE THIS
0

A Fast, Easy Way to Inform Parents About Vaccinations

Officials with the Centers for Disease Control and Prevention have prepared an informational video on this topic.

Pharmacy Times Strategic Alliance
 

Pharmacist Education
Clinical features with downloadable PDFs


Next-Generation Pharmacist® Awards


SIGN UP FOR THE PHARMACY TIMES NEWSLETTER
Personalize the information you receive by selecting targeted content and special offers.