Ibuprofen and acetaminophen may raise blood pressure by blocking production of prostaglandins, hormone-like substances that can widen blood vessels, according to speculation at the heart of a study published in last month?s Archives of Internal Medicine. The study involved more than 80,000 women. It found that, over 2 years, women who reported taking acetamino-phen 22 days a month or more were twice as likely to develop hypertension as women who did not use the drug. Those who took nonsteroidal anti-inflammatory medicines that frequently were 86% more likely to develop hypertension than nonusers.
However, even the authors of the study admit that relying on mail-in questionnaires instead of clinical measurements casts a shadow on the findings. ?If people have chronic pain, and they need analgesics, I would tell them to take them,? said Harvard?s Dr. Gary C. Curhan, the study?s lead author. ?Not everybody who takes these [drugs] gets hypertension?[but] given that these medications are readily available over the counter and are used by a large proportion of the adult population, this association merits further study.?
Women with abnormal vaginal microbiota showed no difference in efficacy of daily oral PrEP compared to women with normal vaginal microbiota.
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