How can I maintain a gel-like product and still incorporate the salicylic acid?
Published Online: Tuesday, October 1, 2002 [ ]
I received a request for 3% salicylic acid to be mixed in 60 g of clobetasol gel. I tried to work the salicylic acid into the gel in the same manner as I would an ointment: levigation of the powder followed by incorporation into the cream. My products lost the gel consistency and ended up as a liquid. How can I maintain a gel-like product and still incorporate the salicylic acid?
|Click Here For The Answer ----------->
A discontinued product, Keralyt Gel, contained salicylic acid in high concentration. It seems to have been removed from the market partly because of instability of the gel: salicylic acid decreases the pH of the preparation. Most gel bases break at low pH.
Here is a suggestion: try levigating the clobetasol as a powder into a gel such as this (Table).
No claims are made as to the uses, safety, efficacy, or bioavailability of this product. The formula is for informational purposes only.
Your comments are valuable to us. Thank you.
Sorry, you must be logged in and registered to post a comment.
To login, click To register, click here.