ASCO Issues Global HPV Vaccination Guidelines for Cervical Cancer Prevention

MARCH 20, 2017
Jennifer Barrett, Assistant Editor
The American Society of Clinical Oncology (ASCO) released a clinical practice guideline on human papillomavirus (HPV) vaccination for the primary prevention of cervical cancer. The updated guidelines are designed for different regions worldwide based on varying socio-economic and structural resource settings.
The recommendations are divided according to 4 levels of resource settings: basic, limited, enhanced, and maximal.
For all environments and independent of resource settings:
  • Two doses of HPV vaccine are recommended for girls aged 9-14 years old, with an interval of at least 6 months and up to 12-15 months between doses.
  • Girls who have HIV should receive 3 doses.
For maximal and enhanced resource settings:
  • If girls are 15 years or older and have received their first dose before age 15, they may complete the 2-dose series.
  • If they have no received first dose before age 15, they should receive 3 doses.
  • In both scenarios, vaccination may be given through age 26 years old.
For limited and basic resource settings: 
  • If sufficient resources remain after vaccinating girls aged 9-14 years old, girls who received 1 dose may receive additional doses between ages 15-16 years old. 
For vaccination of boys in all settings, boys may be vaccinated if there is at least 50% coverage in the priority female target population, sufficient resources, and such vaccination is cost-effective.
The guidelines were developed by a multinational and multidisciplinary panel of oncology, obstetrics/gynecology, public health, cancer control, epidemiology/biostatistics, health economics, behavioral/implementation science, and patient advocacy experts.
Arrossi S, Temin S, Garland S, et al. Primary prevention of cervical cancer. ASCO. Mar. 17, 2017. doi: 10.1200/JGO.2016.008151.
First Global Guidance for HPV Vaccination for Cervical Cancer Prevention [news release]. Virginia. ASCO’s website. Accessed Mar. 20, 2017. 


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