Videos

4 experts are featured in this series.

Panelists discuss how unmet needs in early and metastatic breast cancer include overcoming endocrine resistance, improving adverse effect management, ensuring guideline-concordant care, addressing long-term toxicities, and expanding the role of pharmacists in monitoring, clinical trial integration, and advancing the evolving CDK4/6 inhibitor pipeline.

4 experts are featured in this series.

Panelists discuss how pharmacists and multidisciplinary teams can empower patients with early or metastatic breast cancer through education, adverse effect management, dose adjustments, frequent follow-up, and integration of CDK4/6 inhibitors with other therapies, while addressing logistical and clinical challenges in practice.

3 experts in this video

Panelists discuss how subcutaneous checkpoint inhibitors are appropriate for nearly all patients except those with severe cachexia limiting injection sites, with patient conversations emphasizing equivalent efficacy data, safety profiles, quality of life benefits including potential home administration, and the option to maintain IV therapy for patients who prefer their current regimen.

5 experts are featured in this series

Panelists discuss the long-term safety and durability of CDK4/6 inhibitors, highlighting data supporting sustained efficacy and manageable toxicity over years of treatment.

4 experts are featured in this series.

Panelists discuss how dose reductions for CDK4/6 inhibitors are commonly needed due to neutropenia, thrombocytopenia, diarrhea, and other toxicities but do not compromise efficacy based on subgroup analyses from major trials, while dose escalation strategies (particularly starting abemaciclib at 50 mg and gradually increasing) have been successfully implemented based on the TRADE study data to reduce early discontinuation rates by approximately 50%, though practical challenges exist with pharmacy dispensing and patient questions about why escalation to full dose is necessary when lower doses maintain efficacy.