In a multinational, placebo-controlled trial, rosuvastatin proved to be well-tolerated in patients with dyslipidemia. The 33-trial program included >16,800 patients who represented >25,000 patient-years of continuous exposure to rosuvastatin. The patients received 5 to 40 mg of the drug or placebo. Adverse events occurred in 52.1% of the rosuvastatin group and 51.8% of the placebo group, giving it an adverse-event profile similar to that of atorvastatin 10 to 80 mg, simvastatin 10 to 80 mg, and pravastatin 10 to 40 mg.
One study linked multiple pregnancies to an increased risk of developing atrial fibrillation later in life, and another investigated the association between premature delivery and cardiovascular disease.
Clinical features with downloadable PDFs