Low Birth Weight May Signal Heart Disease

Published Online: Wednesday, June 1, 2005

According to researchers from Johns Hopkins Children's Center, an infant with low birth weight carries particles in the blood that can lower the amount of high-density lipoprotein (HDL) cholesterol that it produces. These particles in the blood contain apolipoprotein C-1, known for lowering HDL, or good cholesterol. Blood from the umbilical cords of 163 infants born at 28 or more gestational weeks and at approximately 1.3 lb less than normal weight were analyzed. Researchers found higher levels of apolipoprotein C-1 in 19% of these infants.

Low birth weight and higher-than-normal levels of this substance have been associated with the death of the heart's smooth-muscle cells. These cells are important to protecting the circulatory system from artery-clogging plaque, which can lead to a heart attack. Researchers concluded that it is important to check C-1 levels in low-birth-weight infants, and that these children should eat low-fat diets to reduce their risk of heart disease.

Latest Articles
Janssen Research and Development LLC has submitted a new drug application to the FDA for canagliflozin and metformin hydrochloride extended release (Invokamet XR).
Treating chronic pulmonary obstructive disease with both inhaled corticosteroids and long-acting bronchodilators remains controversial, but new evidence suggests that this controller combination could reduce mortality risk.
Beverly Schaefer, RPh, of Katterman's Sand Point Pharmacy in Seattle, Washington, shares some fun tips on how to encourage patients who travel to come to your pharmacy for supplies.
Donnie Calhoun, RPh, PD, National Community Pharmacists Association (NCPA) Foundation vice president, discusses how pharmacists can prepare themselves and their business before, during, and after a disaster.
Latest Issues