Parkinson's Drug Quiets RLS

Published Online: Thursday, July 1, 2004

An international study found that the drug pergolide, used to treat patients with Parkinson's disease, appears to work in patients with restless legs syndrome (RLS). This condition, characterized by sensory and motor abnormalities of the limbs associated with an urge to move, afflicts 5% to 10% of the population. In the study, 100 RLS patients in 7 countries were given antinausea medication for 10 to 14 days before taking pergolide or a placebo. (Nausea is a side effect of pergolide.)

The researchers measured sleep efficiency and periodic limb movements (PLMS) during sleep. The severity of RLS was assessed by the validated International RLS Scale. "Our study demonstrates that pergolide substantially improves PLMS measures and subjective sleep disturbances associated with RLS," said study author Claudia Trenkwalder, MD. (The findings were reported in Neurology, April 27, 2004.)

Latest Articles
Donnie Calhoun, RPh, PD, National Community Pharmacists Association (NCPA) Foundation vice president, discusses how pharmacists can prepare themselves and their business before, during, and after a disaster.
Ken Whittemore Jr, Surescript's senior vice president of professional and regulatory affairs, talks about some new transactions available that can help pharmacists.
In case you got caught up in the Thanksgiving holiday rush, here are the top trending stories you may have missed in November:
Bryan Ziegler, PharmD, executive director of Kennedy Pharmacy Innovation Center, provides some resources for community pharmacists to use when implementing new collaborative services with primary care providers.
Latest Issues