HRT Is Linked to Breast Cancer Relapse

Susan Farley
Published Online: Saturday, May 1, 2004

A large, randomized clinical trial of estrogen and progestin as part of a Women's Health Initiative study indicated that breast cancer survivors who took hormone replacement therapy (HRT) to relieve menopausal symptoms had 3 times as many recurrences of cancer as those who did not take HRT. The 1997 Swedish study followed 434 women for a median of 5 years. Researchers found that 26 women in the HRT group and only 7 in the non-HRT group experienced a recurrence of breast cancer. The study was terminated due to the high risk of cancer recurrence from even short-term use of HRT. The study was neither blinded nor placebo-controlled, and recruitment fell short of the 1300- women goal. Despite the study's limitations, JoAnne Zujewski, MD, a medical oncologist specializing in breast cancer at the National Institutes of Health Clinical Center in Bethesda, Md, said, "As a practical matter, given what we already know about the serious risks and extremely limited benefits of HRT, these findings can be considered definitive."



Latest Articles
This weekly video program highlights the latest in pharmacy news, product news, and more.
Propranolol is red, digoxin is blue. Your pharmacist’s heart may skip a beat if they get a valentine from you.
Health-system pharmacists can play a critical role in managing drug shortages to prevent medical errors and adverse events.
The White House is asking Congress for more than $1.8 billion in emergency funding to combat the Zika virus, which is creeping into the United States and ravaging some foreign countries.
Latest Issues
$auto_registration$
VSEO N/A