Statins May Work in Alzheimer's Disease

Published Online: Sunday, June 1, 2003

In a study of 44 patients with Alzheimer?s disease, researchers at the University of Texas Southwestern Medical Center found that statins lowered the patients? brain cholesterol levels. (Brain cholesterol contributes to the formation of amyloid plaques that damage brain cells.) During the 6-week study, participants were randomly assigned to receive either 40 mg daily of 1 of 3 different statins or 1 g daily of extended-release niacin?another kind of cholesterol-lowering drug. The results were published in the Archives of Neurology (April 21, 2003).

The researchers discovered that the 3 statin drugs reduced brain cholesterol levels by at least 20%, whereas the extended-release niacin reduced them by 10%. "This class of drugs [statins] may be potentially beneficial in the treatment of Alzheimer?s disease," said Gloria Vega, PhD, lead author of the study.

Latest Articles
Pharmacists might be surprised to learn that Pinterest is a hotbed for anti-vaccine sentiment.
The FDA has approved betamethasone dipropionate spray, 0.05%, as a treatment for mild to moderate plaque psoriasis in patients aged 18 years and older.
Medication errors injure thousands of patients annually, and while mistakes occur with all medication classes, those involving antiretroviral therapies are particularly troublesome.
Acute respiratory infections such as the common cold are often accompanied by cough and congestion caused by mucus hypersecretion.
Latest Issues