John R. Horn, PharmD, FCCP, and Philip D. Hansten, PharmD
Over the past few years, several new antiviral drugs have been added to the therapeutic options for HCV, including boceprevir, telaprevir, simeprevir, and sofosbuvir. These new therapies have several important drug interactions.
Boceprevir is primarily metabolized by aldo-keto reductase but is also a substrate and inhibitor of CYP3A4 and P-glycoprotein (P-gp).1
In one study, ketoconazole increased the concentration of a single boceprevir dose by 130%. It is unclear whether this degree of increase in boceprevir will result in an increase in side effects (nausea, fatigue, and anemia). Boceprevir-induced CYP3A4 inhibition increased the area under the concentrationtime curve (AUC) of midazolam by 430% and the AUC of atorvastatin by 2.7-fold. Boceprevir has been noted to cause a modest (20%) increase in digoxin levels.2
Inducers of CYP3A4 (eg, rifampin, efavirenz) would be expected to reduce the plasma concentration of boceprevir sufficiently to impede its antiviral efficacy. No data are available regarding the potential for rifampin to reduce boceprevir concentrations, but one should assume that the combination would result in low boceprevir levels; therefore, the combination should be avoided. Boceprevir has been noted to reduce the AUC of atazanavir, lopinavir, and darunavir (35% to 45%) by an undefined mechanism. Some reduction in anti-HIV efficacy could result.
Conversely, ritonavir-boosted lopinavir and darunavir reduced the AUC of boceprevir by 35% to 45%. The AUC of ethinyl estradiol was reduced 24% during concurrent boceprevir administration, but the concentration of the progestin drospirenone was increased by about 100%. The impact of these changes on the risk for pregnancy or hyperkalemia due to drospirenone is unknown. No change in norethindrone levels were noted during boceprevir exposure.2
Telaprevir is a substrate and inhibitor of CYP3A4. In one study, ketoconazole increased the telaprevir concentration by over 60%. While data on the combination of telaprevir and other potent CYP3A4 inhibitors are lacking, one should expect increased telaprevir concentrations during coadministration with other CYP3A4 inhibitors. Signs of an excessive telaprevir concentration include anemia, rash, and nausea. Telaprevir is a potent CYP3A4 inhibitor, increasing the AUC of orally administered midazolam nearly 9-fold. The cyclosporine concentration and half-life increased about 4.5-fold following concurrent telaprevir administration. When telaprevir was administered with tacrolimus, the AUC of tacrolimus increased 70-fold and its half-life increased nearly 5-fold. Telaprevir increased the AUC of amlodipine and atorvastatin by 2.8- and 7.9-fold, respectively.3
One should expect marked increases in the plasma concentration of CYP3A4 substrates when telaprevir is coadministered. Digoxin concentration increased by 85% during telaprevir administration, an indication of its P-gp inhibition.
The AUC of telaprevir has been reported to be reduced by 20% to 50% when telaprevir is coadministered with ritonavir-boosted atazanavir, fosamprenavir, lopinavir, and darunavir. Rifampin reduced the telaprevir concentration by over 90% and should not be used with telaprevir. The AUC of ethinyl estradiol was reduced 28% during concurrent telaprevir administration.