Generic Products

MAY 16, 2011

Exemestane Tablets

Marketed by: Greenstone (Peapack, NJ)

Compared to: Aromasin (Pfizer) Indication: Pfizer’s generic subsidiary Greenstone introduced exemestane tablets, the authorized generic of the breast cancer drug Aromasin. Exemestane is an aromatase inhibitor indicated for the treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have completed a 2- to 3-year course of tamoxifen therapy. It is also used to treat advanced breast cancer in women whose diseased progressed after undergoing treatment with tamoxifen.

Dosage form: Tablets: 25 mg

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Marketed by: Sandoz (Princeton, NJ)

Compared to: Nordette (Duramed Pharmaceuticals)

Indication: Altavera (levonorgestrel and ethinyl estradiol tablets)—a generic equivalent to Duramed’s combined oral contraceptive Nordette—was approved by the FDA for the prevention of pregnancy in women who choose it as a method of contraception. Altavera is supplied in a dosing regimen that is identical to its branded counterpart: a blister card packed with 21 peach-colored active tablets, each containing 0.15 mg levonorgestrel and 0.03 mg ethinyl estradiol, and 7 white inert tablets. Because smoking cigarettes increases the risk of serious cardiovascular side effects from oral contraceptives, pharmacists should strongly advise women not to smoke while taking Altavera.

Dosage Form: Tablets: 0.15 mg levonorgestrel/0.03 mg ethinyl estradiol

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Marketed by: Hospira (Lake Forest, IL)

Compared to: Taxotere (sanofi-aventis)

Indication: Hospira announced the FDA approval and launch of docetaxel, a generic version of sanofi-aventis’s Taxotere. Docetaxel is a microtubule inhibitor indicated for the treatment of breast cancer, nonsmall cell lung cancer, hormone refractory prostate cancer, gastric adenocarcinoma, and locally advanced squamous cell carcinoma of the head and neck. Hospira’s version of docetaxel is supplied in a single-vial formulation that can be directly injected into the infusion container, reducing the number of handling steps required to prepare the medication.

Dosage Form: Vials: 20, 80, and 160 mg of docetaxel at a 10 mg/mL concentration

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Methylphenidate Hydrochloride extended-release tablets

Marketed by: Watson Laboratories, a subsidiary of Watson Pharmaceuticals (Parsippany, NJ)

Compared to: Concerta (Ortho-McNeil-Janssen Pharmaceuticals)

Indication: Under an exclusive agreement with Ortho-McNeil-Janssen, Watson subsidiary Watson Laboratories launched methylphenidate hydrochloride extended-release tablets, an authorized generic version of Concerta. Methylphenidate is a mild central nervous system stimulant indicated as part of a total treatment program for attention-deficit/hyperactivity disorder that may also include psychological, educational, and social measures. The recommended initial dose is 18 mg for children and either 18 or 36 mg for adults, taken once daily. Dosage may be increased by 18 mg per day at weekly intervals, and should not exceed 54 mg per day in children and 72 mg per day for adults and adolescents.

Dosage Form: Extended-release tablets: 18, 27, 36, and 54 mg

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