compounding HOTLINE

APRIL 01, 2008
Martin A. Erickson III, RPh

Mr. Erickson is director of professional affairs at Gallipot Inc.



Schamberg's Lotion was commercially available at one time. We cannot find a source now.


Various formulations have been used. According to Martindale, The Extra Pharmacopoeia, 27th ed:

Zinc oxide

8 g

Menthol

0.25 g

Phenol

0.5 g

Calcium hydroxide solution (lime water)*

46 mL

Olive oil qs ad

100 mL

Suggested Method of Preparation
*Prepare calcium hydroxide solution (saturated) prior to use. Combine 10 g with 1000 mL purified water by shaking well; allow to stand covered overnight. Filter to remove the excess. The solution should not contain <0.15% CaOH2.

  1. Calculate ingredient amounts required for the preparation.
  2. Weigh/measure ingredients.
  3. Dissolve the menthol and the phenol in the olive oil.
  4. Add calcium hydroxide solution; shake well to form an emulsion.
  5. Add the zinc oxide, stirring until smooth.
  6. If emulsion is not achieved and is desired, add 2 to 3 drops of Oleic acid and stir well.

Alternative Formulation, Medicated Emollient Suspension

Menthol

600 mg

Phenol

400 mg

Zinc oxide

20 g

Olive oil qs ad

120 mL

Calcium hydroxide solution (lime water)*

120 mL

(Note that total volume is >240 mL.)

Further modification increased the phenol concentration considerably—"full-strength" Schamberg's Lotion has phenol 4 g.

Package in tight, light-resistant containers. Label: "shake well" and "external use."

E-mail your compounding questions to .




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