compounding HOTLINE

Martin A. Erickson III, RPh
Published Online: Thursday, November 1, 2007

Mr. Erickson is director of professional affairs at Gallipot Inc.



Do you have a formulation for extemporaneous preparation of prednisolone suspension? I have a pediatric patient who cannot tolerate the manufactured preparation.


Prednisolone Sodium Phosphate Oral Solution #1 (sugar-free, alcohol-free, dye-free) Calculated to make 100 mL


Ingredients:
Prednisolone sodium phosphate 0.135 g
Sorbitol 70% USP 50.0 mL
Sodium saccharin 0.500 g
*Flavor concentrate 1.0 mL
Distilled water USP qs ad 100.0 mL
*Raspberry, strawberry, or cherry.

Supplies:
Balance with weights and weigh paper or weigh boats
Graduated cylinder
Mortar and pestle
Beaker
Stirring rod

Procedure:

  1. Dissolve the prednisolone sodium phosphate and the sodium saccharin in 40 mL of distilled water.
  2. Add the sorbitol 70% USP and flavor concentrate to (1) with stirring.
  3. Add sufficient distilled water to (2) to make 100 mL.

Notes: No claims are made as to the uses, safety, efficacy, or bioavailability of this product.

The formula is for informational purposes only.

E-mail your compounding questions to .




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