Levofloxacin as Effective as Ciprofloxacin for cUTI, Acute Pyelonephritis

Susan Farley
Published Online: Sunday, July 1, 2007

A once-daily, 750-mg dose of levofloxacin (Levaquin) taken for 5 days has been shown to be as effective as a 10-day, 400- to 500-mg regimen of ciprofloxacin for the treatment of complicated urinary tract infections (cUTI) and acute pyelonephritis (AP). Levofloxacin's manufacturer, Ortho-McNeil Inc, conducted a multicenter, double-blind, randomized study of 1109 patients with either cUTI or AP who received either the levofloxacin therapy or the ciprofloxacin therapy. Resolution or improvement of urinary symptoms was similar for both therapies, with common adverse events being nausea, headache, and diarrhea. Data from the study were presented recently at the annual meeting of the American Urological Association.

Latest Articles
This weekly video program provides our readers with an in-depth review of the latest news, product approvals, FDA rulings and more.
Chronic kidney disease incidence has grown faster than many of its common comorbidities such as diabetes and hypertension, and medications may be an underappreciated driver of this growth.
President Barack Obama’s fiscal year 2017 budget proposal calls for an additional $1.1 billion to combat the nation’s spiraling opioid epidemic.
Baxter International is voluntarily recalling intravenous solution due to leaking containers and the potential for particulate matter.
Latest Issues