ACETAMINOPHEN INTERACTION MAY PUT PATIENTS AT RISK

JULY 01, 2007
Anna D. Garrett, PharmD, BCPS, CPP

A recently published randomized, double- blind, placebo-controlled study of 36 patients with stable international normalized ratios (INRs) demonstrated a clinically significant interaction between warfarin and high-dose acetaminophen (2-4 g/day).

Patients were randomized to receive placebo, 2 g of acetaminophen per day, or 4 g of acetaminophen per day. A stable INR was defined as 2 consecutive INRs at least 3 weeks apart that were in the therapeutic range.

Of the 24 patients assigned to an acetaminophen group, 13 had elevated INRs over the course of the 4-week study period. Two patients had elevated INRs in the placebo group.

INRs returned to normal in 83% of patients when acetaminophen was discontinued.



SHARE THIS SHARE THIS
0
 

In Seniors: Consider CMV Serostatus
When Recommending Flu Vaccine

Older people who have cytomegalovirus seem to have less robust responses to the trivalent influenza vaccine than those who do not have CMV.


 

 

Conference Coverage
News from the year's biggest meetings


Pharmacist Education
Clinical features with downloadable PDFs


 

SIGN UP FOR THE PHARMACY TIMES NEWSLETTER
Personalize the information you receive by selecting targeted content and special offers.