Anxiety Disorders Helped by Antipsychotics

Susan Farley
Published Online: Thursday, February 1, 2007

A recent data review revealed that the antipsychotic drug trifluoperazine is welltolerated and more effective than placebo for the short-term treatment of generalized anxiety disorder. Researchers from the University Hospitals of Cleveland/Case Western Reserve University conducted the review to determine how effective an antipsychotic drug would be in treating anxiety. Researchers looked at studies of bipolar disorder and major depressive disorders that included anxiety-related changes. Keming Gao, MD, PhD, of the review team said, "We found that, in a well-designed study, low doses of trifluoperazine?were well-tolerated and superior to placebo. In less welldesigned studies, other?antipsychotics appeared to be superior to placebo and might be as effective as sedative drugs in the short-term treatment of generalized anxiety disorders." Results also showed that, when compared with placebo, the antipsychotics olanzapine and quetiapine significantly reduced symptoms of anxiety in patients with bipolar disorder.

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