Rebound Insomnia: Some Medications Are Created Equal

Published Online: Monday, May 1, 2006

Short-term studies have suggested that newer hypnotic agents, such as zolpidem, produce less rebound insomnia, compared with benzodiazepines. Research reported in European Neuropsychopharmacology (August 2004), however, showed that zolpidem is not superior to the benzodiazepine temazepam with respect to rebound insomnia.

Rebound insomnia may occur after patients stop taking certain sleep medications. A randomized, controlled trial compared the prevalence of rebound insomnia in zolpidem-and temazepam-treated patients after they discontinued treatment for chronic insomnia.

During the initial 4-week treatment period, equivalent doses of both agents were comparably safe and efficacious in improving total sleep time (TST) and sleep onset latency (SOL). After cessation of treatment, the prevalence of rebound insomnia, which was defined by a worsening of TST or SOL, also was similar with both agents. Therefore, it appears that at least one of the newer "Z drugs," zolpidem, has no advantages over temazepam in clinical use for insomnia or for rebound insomnia.

Latest Articles
In case you got caught up in the Thanksgiving holiday rush, here are the top trending stories you may have missed in November:
Bryan Ziegler, PharmD, executive director of Kennedy Pharmacy Innovation Center, provides some resources for community pharmacists to use when implementing new collaborative services with primary care providers.
James Schiffer, RPh, associate at Allegaert Berger & Vogel LLC, discusses some tips for pharmacists who are facing a Drug Enforcement Administration audit.
Carlos Aquino, founder and president of PharmaDiversion LLC, talks about the importance of the Drug Enforcement Administration's (DEA) diversion website.
Latest Issues