Long-term LNG/EE Use Does Not Hinder Future Ovulation

Susan Farley
Published Online: Saturday, April 1, 2006

The results of a single-center, singletreatment, open-label study show that the long-term use of Wyeth's oral levonorgestrel (LNG) 90 μg/ethinyl estradiol (EE) 20 μg had no ill effects on the resumption of ovulation after stopping treatment. The study involved healthy women aged 18 to 35 years who participated for ~8 months, including up to 84 days of posttreatment observation for the return of ovulation. Ovarian activity was assessed by measuring progesterone and other hormone levels 3 times per week during treatment. Of the 58 participants who received the treatment, 37 completed the study successfully and showed no signs of ovulation during treatment. After treatment was ended, all these patients resumed ovulation within 31 days; 7 resumed between days 8 and 14. The study results were presented at the Annual Meeting of the American Society for Reproductive Medicine on October 17, 2005.

Ms. Farley is a freelance medical writer based in Wakefield, RI.

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