A combination of therapies for the relief of rheumatoid arthritis (RA) was found to have a greater effect than either therapy alone, as reported in the January 2006 issue of Arthritis & Rheumatism. A 2-year study involved 539 patients who had had active RA for <3 years.
The patients (mean age 52) were divided into 3 groups: one group received methotrexate; another group received injections of adalimumab; and the third group received both treatments. All groups were evaluated at 6, 12, and 24 months.
After 1 year, 62% of those on combination therapy had a 50% improvement in symptoms, compared with 41% of the adalimumab group and 46% of the methotrexate group. At 2 years, nearly half of the patients on combination therapy exhibited major clinical remissionabout twice as many as either of the other groups.
One study linked multiple pregnancies to an increased risk of developing atrial fibrillation later in life, and another investigated the association between premature delivery and cardiovascular disease.
Clinical features with downloadable PDFs