Small Intestinal Bacterial Overgrowth in IBS

Published Online: Monday, August 1, 2005

Small intestinal bacterial overgrowth (SIBO)—detected using the lactulose breath test—and sugar malabsorption—detected using hydrogen lactose, fructose, and sorbitol breath tests—may have roles in irritable bowel syndrome (IBS). In Alimentary Pharmacology and Therapeutics (June 2005), Gabriella Nucera, MD, and colleagues assessed the influence of SIBO on hydrogen lactulose and sugar breath tests in 98 IBS patients before and after eradication therapy.

The lactulose breath test results were positive for 64 (65%) of the 98 patients. These patients had significantly higher positive results on lactose (P < .05), fructose (P < .01), and sorbitol (P < .01) breath tests, compared with patients without SIBO. After antibiotic treatment, eradication of bacteria resulted in a significant reduction in positive findings on sugar breath tests (17% vs 100%, 3% vs 62%, and 10% vs 71%, respectively; P < .0001), suggesting that sugar malabsorption findings may be falsely positive in patients with SIBO. Eradication of SIBO may normalize sugar breath levels. Therefore, tests for SIBO should be conducted before other sugar breath tests to avoid sugar malabsorption misdiagnosis.

Latest Articles
This weekly video program provides our readers with an in-depth review of the latest news, product approvals, FDA rulings and more.
Chronic kidney disease incidence has grown faster than many of its common comorbidities such as diabetes and hypertension, and medications may be an underappreciated driver of this growth.
President Barack Obama’s fiscal year 2017 budget proposal calls for an additional $1.1 billion to combat the nation’s spiraling opioid epidemic.
Baxter International is voluntarily recalling intravenous solution due to leaking containers and the potential for particulate matter.
Latest Issues