Older women who take diuretics with calcium channel blockers may be increasing their risk of death, compared with taking diuretics plus beta-blockers or angiotensin-converting enzyme (ACE) inhibitors. The findings are based on a study of >30,000 women reported in the Journal of the American Medical Association (December 15, 2004). The 6-year study included 30, 219 women aged 50 to 79 with hypertension but no history of cardiovascular disease, including 18,969 who were taking at least 1 blood pressure drug.
The number of heart-related deaths was smallspecifically, 31 out of 1223 women taking the calcium channel blocker combination, versus 18 out of 1380 on the beta-blocker combination and 17 out of 1413 on the ACE inhibitor combo. Lead author Sylvia Wassertheil-Smoller, PhD, advised women on the first 2- drug combination to speak with their physicians about why they prescribed calcium channel blockers.
One study linked multiple pregnancies to an increased risk of developing atrial fibrillation later in life, and another investigated the association between premature delivery and cardiovascular disease.
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