Antidiabetic Drug Improves Glycemic Control, Insulin Sensitivity

Susan Farley
Published Online: Friday, October 1, 2004

A long-term study of the oral antidiabetic drug pioglitazone HCl (Actos) revealed that its use either alone or in combination with other oral antidiabetic medications resulted in sustained improvements in glycemic control, insulin sensitivity, and prominent lipid parameters. Conducted over a 2-year period, the study combined pioglitazone HCl with 2 other common antidiabetic medications: gliclazide and metformin. More than 1200 patients were followed over the 2-year period, and 4 different regimens were evaluated.

The results showed that, regardless of whether pioglitazone HCl was combined with metformin or with gliclazide, there was a significant reduction in fasting insulin, and these decreases were sustained over a period of 2 years. Researchers determined that Actos helps the body use its insulin more efficiently, thereby reducing fasting insulin and reducing demand on the pancreatic beta cells.

Latest Articles
This weekly video program provides our readers with an in-depth review of the latest news, product approvals, FDA rulings and more.
Chronic kidney disease incidence has grown faster than many of its common comorbidities such as diabetes and hypertension, and medications may be an underappreciated driver of this growth.
President Barack Obama’s fiscal year 2017 budget proposal calls for an additional $1.1 billion to combat the nation’s spiraling opioid epidemic.
Baxter International is voluntarily recalling intravenous solution due to leaking containers and the potential for particulate matter.
Latest Issues